Kcnt2 Gene Summary [Rat]
Enables chloride-activated potassium channel activity. Involved in potassium ion export across plasma membrane. Acts upstream of or within potassium ion transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 57. Orthologous to human KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnt2 |
| Official Name | potassium sodium-activated channel subfamily T member 2 [Source:RGD Symbol;Acc:735074] |
| Ensembl ID | ENSRNOG00000013312 |
| Bio databases IDs | |
| Aliases | potassium sodium-activated channel subfamily T member 2 |
| Synonyms | DEE57, E330038N15Rik, EIEE57, KCa4.2, KNa1.2, potassium channel, subfamily T, member 2, potassium sodium-activated channel subfamily T member 2, SLICK, SLO2.1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- Calcium-activated BK potassium channel alpha subunit
- Ion transport protein
- channel/pore class transporter
- ATP binding
- intracellular sodium activated potassium channel
- ligand-gated ion channel
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- intracellular sodium activated potassium channel activity
- ATP binding
- chloride-activated potassium channel activity
- outward rectifier potassium channel activity