Acvr2b Gene Summary [Rat]
Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development and response to activity. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in visceral heterotaxy 4. Orthologous to human ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acvr2b |
| Official Name | activin A receptor type 2B [Source:RGD Symbol;Acc:2028] |
| Ensembl ID | ENSRNOG00000014477 |
| Bio databases IDs | |
| Aliases | activin A receptor type 2B |
| Synonyms | 4930516B21Rik, activin A receptor type 2B, activin receptor IIB, ActR2B, ACTRIIB, AI047905, AI850658, HTX4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acvr2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein threonine/tyrosine kinase
- Protein tyrosine and serine/threonine kinase
- activin binding
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- type II activin receptor
- Protein Kinases, catalytic domain
- transmembrane receptor protein serine/threonine kinase
- transmembrane domain
- intracellular domain
- kinase activator
- TFP
- PDZ binding motif
- Tyrosine kinase, catalytic domain
- growth factor binding
- transmembrane receptor
- cytoplasmic kinase domain
Pathways
Biological processes and signaling networks where the Acvr2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- Cellular Effects of Sildenafil (Viagra)
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- GADD45 Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- PPARα/RXRα Activation
- RAR Activation
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Tissue Factor in Cancer
- TGF-β Signaling
- Th1 and Th2 Activation Pathway
- Th2 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- iron overload
- cyanosis
- atrial septal defect
- autosomal 4 visceral heterotaxy
- splenomegaly
- osteoporosis
- mesocardia
- anemia
- osteogenesis imperfecta type III
- transposition of great vessel
role in cell
- differentiation
- apoptosis
- activation in
- quantity
- survival
- morphology
- ossification by
- hyperactivation in
- homeostasis in
- lifespan
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acvr2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina vasculature development in camera-type eye
- organ growth
- insulin secretion
- post-embryonic development
- palate development
- anterior/posterior pattern specification
- mesoderm development
- odontogenesis of dentin-containing tooth
- transmembrane receptor protein serine/threonine kinase signaling pathway
- positive regulation of osteoblast differentiation
- artery development
- protein phosphorylation
- venous blood vessel development
- embryonic foregut morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- activin receptor signaling pathway
- heart development
- response to glucose stimulus
- kidney development
- BMP signaling pathway
- gastrulation with mouth forming second
- positive regulation of activin receptor signaling pathway
- lymphangiogenesis
- positive regulation of bone mineralization
- lung development
- pancreas development
- signal transduction
- regulation of transcription, DNA-dependent
- lymphatic endothelial cell differentiation
- skeletal system morphogenesis
- determination of left/right symmetry
- blood vessel remodeling
- cellular response to growth factor stimulus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- activin receptor complex
- macromolecular complex
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- kinase activator activity
- ATP binding
- growth factor binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- activin binding
- metal ion binding
- activin receptor activity, type II
- activin-activated receptor activity
- protein serine/threonine kinase activity