Slco4c1 Gene Summary [Rat]
Predicted to enable sodium-independent organic anion transmembrane transporter activity. Involved in organic anion transport. Located in basolateral plasma membrane. Biomarker of kidney failure. Orthologous to human SLCO4C1 (solute carrier organic anion transporter family member 4C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slco4c1 |
| Official Name | solute carrier organic anion transporter family, member 4C1 [Source:RGD Symbol;Acc:1303048] |
| Ensembl ID | ENSRNOG00000022711 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family, member 4C1 |
| Synonyms | 9530051F04, C330017E21RIK, OATP4C1, OATP-H, OATP-M1, oatp-R, OATPX, PRO2176, SLC21A20, solute carrier organic anion transporter family member 4C1, solute carrier organic anion transporter family, member 4C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slco4c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- organic anion transporter
- KAZAL_FS
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- preeclampsia
- restless legs syndrome
regulates
- digoxin
- organic anion
- sitagliptin
- SLCO4C1
role in cell
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- secretory granule membrane
- specific granule membrane
- basolateral membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slco4c1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- transmembrane transport
- spermatogenesis
- sodium-independent organic anion transport
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- azurophil granule membrane
- basolateral plasma membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity