Il4r Gene Summary [Rat]
Predicted to enable interleukin-4 receptor activity. Involved in regulation of cell population proliferation; response to estrogen; and response to odorant. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il4r |
| Official Name | interleukin 4 receptor [Source:RGD Symbol;Acc:2899] |
| Ensembl ID | ENSRNOG00000015441 |
| Bio databases IDs | |
| Aliases | interleukin 4 receptor |
| Synonyms | CD124, IL-4RA, IL4R alpha, Il4r beta, IL-4 receptor, il 4 receptor α chain, IL-4R-α, Il4r β, interleukin 4 receptor, interleukin 4 receptor, alpha, interleukin 4 receptor, α, MFF receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il4r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-4 receptor
- ectodomain
- Interleukin-4 receptor alpha chain, N-terminal
- NPXF motif
- protein binding
- Fibronectin type 3 domain
- acidic domain
- membrane distal domain
- docking domain
- ID-1 domain
- binding protein
- serine-rich region
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- FN3
- intracellular domain
- Insulin/Il4 receptor motif
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il4r gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Glucocorticoid Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-4 Signaling
- Molecular Mechanisms of Cancer
- p70S6K Signaling
- PI3K Signaling in B Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- STAT3 Pathway
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- metastasis
- advanced cancer
- cancer
- neoplasia
- hyperactive behavior
- hyperplasia
- endometriosis
- atopic dermatitis
- sinonasal polyposis
role in cell
- expression in
- proliferation
- activation in
- binding
- phosphorylation in
- function
- apoptosis
- activation
- production in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- centrosome
- apical cell surfaces
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il4r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mast cell degranulation
- interleukin-4-mediated signaling pathway
- signal transduction
- positive regulation of T-helper 2 cell differentiation
- negative regulation of T-helper 1 cell differentiation
- defense response to protozoan
- T-helper 1 cell differentiation
- production of molecular mediator involved in inflammatory response
- T-helper 2 cell differentiation
- immune response
- cytokine-mediated signaling pathway
- positive regulation of macrophage activation
- immunoglobulin mediated immune response
- positive regulation of immunoglobulin production
- positive regulation of chemokine production
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-4 receptor activity
- cytokine receptor activity