Cops2 Gene Summary [Rat]
Predicted to enable transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and neuron differentiation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cops2 |
| Official Name | COP9 signalosome subunit 2 [Source:RGD Symbol;Acc:628791] |
| Ensembl ID | ENSRNOG00000008744 |
| Bio databases IDs | |
| Aliases | COP9 signalosome subunit 2 |
| Synonyms | ALIEN, COP9 signalosome subunit 2, CSN2, SGN2, TRIP-15 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cops2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- transcription co-repressor
- protein binding
Pathways
Biological processes and signaling networks where the Cops2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian neoplasm
- ovarian neoplasia
- hyperinsulinism
- mammary neoplasm
- non-insulin-dependent diabetes mellitus
- colon neoplasm
- colorectal neoplasia
- lung neoplasm
- thyroid gland neoplasm
role in cell
- activation in
- proliferation
- expression in
- differentiation
- G1/S phase transition
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cops2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- skeletal muscle cell differentiation
- neuron differentiation
- signal transduction
- inner cell mass cell proliferation
- trophectodermal cell proliferation
- transcription from RNA polymerase II promoter
- protein neddylation
- protein deneddylation
- protein phosphorylation
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- signalosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity