Crisp1 Gene Summary [Rat]
Predicted to enable calcium channel regulator activity. Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to act upstream of or within regulation of acrosome reaction. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crisp1 |
| Official Name | cysteine-rich secretory protein 1 [Source:RGD Symbol;Acc:1590757] |
| Ensembl ID | ENSRNOG00000013612 |
| Bio databases IDs | |
| Aliases | cysteine-rich secretory protein 1 |
| Synonyms | Aeg1, AEGL1, AEG-like, ARP, Crisp4, cysteine-rich secretory protein 1, HEL-S-57, HSCRISP1D, HSCRISP1G, HUMARP, SCP 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crisp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crisp
- SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
- CAP
- calcium channel regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- secretory vesicles
- specific granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crisp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- regulation of acrosome reaction
- fusion of sperm to egg plasma membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
Molecular Function
What the gene product does at the molecular level
- calcium channel regulator activity