Plcd3 Gene Summary [Rat]
Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Predicted to be involved in intracellular signal transduction and lipid catabolic process. Predicted to act upstream of or within angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Predicted to be active in plasma membrane. Orthologous to human PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plcd3 |
| Official Name | phospholipase C, delta 3 [Source:RGD Symbol;Acc:1310903] |
| Ensembl ID | ENSRNOG00000003033 |
| Bio databases IDs | |
| Aliases | phospholipase C, delta 3 |
| Synonyms | 2610205J15RIK, mKIAA1964, phospholipase C delta 3, phospholipase C, delta 3, phospholipase C δ 3, phospholipase C, δ 3, PLC-delta-3, PLC-δ-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plcd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-specific phospholipase C, Y domain
- enzyme
- Pleckstrin homology-like domain
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- EFh_PI-PLC
- phosphoinositide phospholipase C
- Phosphatidylinositol-specific phospholipase C, X domain
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- EF hand
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the Plcd3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Leptin Signaling in Obesity
- Melatonin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insomnia
- hypertension
- alopecia
- male infertility
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- migraines
role in cell
- cell viability
- G1 phase
- proliferation
- apoptosis
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plcd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- labyrinthine layer blood vessel development
- angiogenesis
- lipid catabolic process
- regulation of cell proliferation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- cytoplasm
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- metal ion binding