Secisbp2 Gene Summary [Rat]
Enables mRNA 3'-UTR binding activity and selenocysteine insertion sequence binding activity. Involved in positive regulation of selenocysteine incorporation and selenocysteine incorporation. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in thyroid gland disease. Orthologous to human SECISBP2 (SECIS binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Secisbp2 |
| Official Name | SECIS binding protein 2 [Source:RGD Symbol;Acc:620991] |
| Ensembl ID | ENSRNOG00000013773 |
| Bio databases IDs | |
| Aliases | SECIS binding protein 2 |
| Synonyms | 2210413N07Rik, 2810012K13Rik, LOC100131231, SBP2, SECIS binding protein 2, THMA1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Secisbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- mRNA 3' UTR binding
- mRNA binding
- ribonucleoprotein binding
- protein binding
- DNA binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Secisbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- selenocysteine incorporation
- striatum development
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- forebrain neuron development
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- ribonucleoprotein complex binding
- selenocysteine insertion sequence binding
- mRNA 3'-UTR binding