SECISBP2 Gene Summary [Human]
The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | SECISBP2 |
| Official Name | SECIS binding protein 2 [Source:HGNC Symbol;Acc:HGNC:30972] |
| Ensembl ID | ENSG00000187742 |
| Bio databases IDs | |
| Aliases | SECIS binding protein 2, Sec insertion sequence-binding protein 2, Selenocysteine insertion sequence-binding protein 2 |
| Synonyms | 2210413N07Rik, 2810012K13Rik, LOC100131231, SBP2, SECIS binding protein 2, THMA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SECISBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- mRNA 3' UTR binding
- mRNA binding
- ribonucleoprotein binding
- protein binding
- DNA binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SECISBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- selenocysteine incorporation
- striatum development
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- forebrain neuron development
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- ribonucleoprotein complex binding
- selenocysteine insertion sequence binding
- mRNA 3'-UTR binding