Fbxl17 Gene Summary [Rat]
Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | Fbxl17 |
| Official Name | F-box and leucine-rich repeat protein 17 [Source:RGD Symbol;Acc:1309773] |
| Ensembl ID | ENSRNOG00000013875 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 17 |
| Synonyms | 6330576B01Rik, BB073797, C130023C01Rik, Fbl17, F-box and leucine-rich repeat protein 17, Fbx13, FBXO13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbxl17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- F-box-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- bipolar disorder
- coronary artery disease
- schizophrenia
- pervasive developmental disorder
- metabolic syndrome X
- post-traumatic stress disorder
- head and neck cancer
- head and neck neoplasia
- insomnia
regulated by
- WAKMAR1
role in cell
- proliferation
- binding in
- signaling in
- ubiquitination in
- proteolysis in
- turnover in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbxl17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- misfolded or incompletely synthesized protein catabolic process
- neural crest cell differentiation
- protein polyubiquitination
- entrainment of circadian clock by photoperiod
- nervous system development
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of smoothened signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding