Fbxl17 Gene Summary [Mouse]
Predicted to be involved in several processes, including protein polyubiquitination; proteolysis involved in protein catabolic process; and regulation of smoothened signaling pathway. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in inferior colliculus; midbrain ventricular layer; and ventral grey horn. Orthologous to human FBXL17 (F-box and leucine rich repeat protein 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxl17 |
| Official Name | F-box and leucine-rich repeat protein 17 [Source:MGI Symbol;Acc:MGI:1354704] |
| Ensembl ID | ENSMUSG00000023965 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 17 |
| Synonyms | 6330576B01Rik, BB073797, C130023C01Rik, Fbl17, F-box and leucine-rich repeat protein 17, Fbx13, FBXO13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- F-box-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- bipolar disorder
- coronary artery disease
- schizophrenia
- pervasive developmental disorder
- metabolic syndrome X
- post-traumatic stress disorder
- head and neck cancer
- head and neck neoplasia
- insomnia
regulated by
- WAKMAR1
role in cell
- proliferation
- binding in
- signaling in
- ubiquitination in
- proteolysis in
- turnover in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- misfolded or incompletely synthesized protein catabolic process
- neural crest cell differentiation
- protein polyubiquitination
- entrainment of circadian clock by photoperiod
- nervous system development
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of smoothened signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding