Tmem126a Gene Summary [Rat]
Predicted to be involved in mitochondrial protein quality control; mitochondrion organization; and optic nerve development. Predicted to act upstream of or within toll-like receptor 4 signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in optic atrophy 7. Orthologous to human TMEM126A (transmembrane protein 126A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem126a |
| Official Name | transmembrane protein 126A [Source:RGD Symbol;Acc:1305677] |
| Ensembl ID | ENSRNOG00000022748 |
| Bio databases IDs | |
| Aliases | transmembrane protein 126A |
| Synonyms | 1810020E01Rik, OPA7, RGD1305677, T126A, transmembrane protein 126A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmem126a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein 126
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmem126a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein insertion into mitochondrial membrane from inner side
- toll-like receptor 4 signaling pathway
- mitochondrial respiratory chain complex I assembly
- optic nerve development
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
- plasma membrane