Rpsa Gene Summary [Rat]
Predicted to enable DNA binding activity; laminin binding activity; and ribosome binding activity. Predicted to be a structural constituent of ribosome. Involved in cell-cell adhesion and epithelial cell differentiation. Located in basement membrane; collagen-containing extracellular matrix; and neuronal cell body. Part of cytosolic small ribosomal subunit. Biomarker of irritable bowel syndrome and sciatic neuropathy. Orthologous to several human genes including RPSA (ribosomal protein SA). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpsa |
| Official Name | ribosomal protein SA [Source:RGD Symbol;Acc:71026] |
| Ensembl ID | ENSRNOG00000018645 |
| Bio databases IDs | |
| Aliases | ribosomal protein SA |
| Synonyms | 37LRP, 40kDa Ribosomal, 40S RIBOSOMAL protein SA, 67LR, ICAS, LAMBR, LAMININ receptor, LAMININ receptor 1, Lamr, LAMR1, Lamrl1, LBP, LBP/p40, LPS-binding, LRP, LRP/LR, MLR, NEM/1CHD4, P40, P40-3, P40-8, ribosomal protein SA, SA, SA p40, uS2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rpsa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein binding
- DNA binding
- translation regulator
- RPS2
- structural constituent of ribosome
- laminin binding
- cytoplasmic domain
- Ribosomal protein S2
- transmembrane domain
- ribosome binding
- laminin receptor
- laminin binding domain
- 40S ribosomal protein SA C-terminus
Pathways
Biological processes and signaling networks where the Rpsa gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- isolated congenital asplenia
- Huntington disease
- melanoma
- melanoma cancer
- growth failure
- Hirschsprung disease
- hepatitis B virus-related hepatocellular carcinoma
- dysplasia
role in cell
- cell viability
- expression in
- phosphorylation in
- degradation in
- replication in
- growth
- migration
- invasion
- binding
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- cell periphery
- cellular membrane
- ribosome
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
- synapse
- extracellular matrix
- perikaryon
- phagosomes
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rpsa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cytoplasmic translation
- cell adhesion
- ribosomal small subunit assembly
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosolic ribosome
- cytoplasm
- cytosolic small ribosomal subunit
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- structural constituent of ribosome
- ribosome binding
- laminin receptor activity
- viral receptor activity
- laminin binding