Krt13 Gene Summary [Rat]
Predicted to enable structural molecule activity. Involved in cellular response to retinoic acid and tongue morphogenesis. Predicted to be located in extracellular exosome and intermediate filament cytoskeleton. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in white sponge nevus 2. Orthologous to human KRT13 (keratin 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt13 |
| Official Name | keratin 13 [Source:RGD Symbol;Acc:1302937] |
| Ensembl ID | ENSRNOG00000014070 |
| Bio databases IDs | |
| Aliases | keratin 13 |
| Synonyms | CK13, K13, K1C13, Ka13, Ker47, keratin 13, Keratin complex 1, acidic, gene 13, Krt-1.13, KRT1-13, WSN2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Krt13 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillomatosis
- white sponge nevus 2
- organismal death
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- squamous-cell carcinoma
- squamous cell cancer
- chronic periodontal disease
- papilloma
role in cell
- G1/S phase transition
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- cytoskeleton
- membrane surface
- cytosol
- keratin intermediate filaments
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- cytoskeleton organization
- intermediate filament organization
- regulation of translation in response to stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- keratin filament
- extracellular vesicular exosome
- cytoskeleton
- intermediate filament cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity