Cand1 Gene Summary [Rat]
Enables TBP-class protein binding activity. Involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cand1 |
| Official Name | cullin-associated and neddylation-dissociated 1 [Source:RGD Symbol;Acc:620479] |
| Ensembl ID | ENSRNOG00000007834 |
| Bio databases IDs | |
| Aliases | cullin-associated and neddylation-dissociated 1 |
| Synonyms | 2310038O07Rik, 6330512O03Rik, cullin associated and neddylation disassociated 1, cullin-associated and neddylation-dissociated 1, D10ERTD516E, mKIAA0829, Similar to CLIP-170-related, TIP120, TIP120A, Tp120a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cand1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- HEAT-like repeat
- TATA-binding protein interacting (TIP20)
- protein binding
- TATA-binding protein binding
Pathways
Biological processes and signaling networks where the Cand1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nonalcoholic fatty liver disease
- hepatic injury
- idiopathic scoliosis
- preeclampsia
- peripheral arterial disease
role in cell
- differentiation
- expression in
- apoptosis
- binding in
- proliferation
- accumulation in
- CSN5i-3 sensitivity
- activation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- growth cone
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cand1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of catalytic activity
- cell differentiation
- SCF complex assembly
- protein ubiquitination
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- ubiquitin ligase complex
- cytoplasm
- cullin-RING ubiquitin ligase complex
- membrane
- cytosol
- secretory granule lumen
- Golgi apparatus
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- TBP-class protein binding