Farsb Gene Summary [Rat]
Predicted to enable ATP binding activity; RNA binding activity; and magnesium ion binding activity. Predicted to contribute to phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to be part of phenylalanine-tRNA ligase complex. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Farsb |
| Official Name | phenylalanyl-tRNA synthetase subunit beta [Source:RGD Symbol;Acc:1303210] |
| Ensembl ID | ENSRNOG00000014119 |
| Bio databases IDs | |
| Aliases | phenylalanyl-tRNA synthetase subunit beta |
| Synonyms | Farsa, Farsl, FARSLB, FRSB, HSPC173, NEDBLLA, PheHB, PHENYLALANYL tRNA SYNTHETASE beta CHAIN, phenylalanyl-tRNA synthetase, beta subunit, phenylalanyl-tRNA synthetase subunit beta, phenylalanyl-tRNA synthetase subunit β, PHENYLALANYL tRNA SYNTHETASE β CHAIN, phenylalanyl-tRNA synthetase, β subunit, PheRS, RILDBC, RILDBC1, RJBS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Farsb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA synthetase B5 domain
- B3/4 domain
- class_II_aaRS-like_core
- enzyme
- protein binding
- phenylalanyl-tRNA synthetase, beta subunit
- magnesium ion binding
- Phe-tRNA synthetase beta subunit B1 domain
- Phenylalanyl tRNA synthetase beta chain CLM domain
- phenylalanine-tRNA ligase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- Alzheimer disease
- Parkinson disease
- Rajab interstitial lung disease with brain calcifications-1
- schizophrenia
- Rajab syndrome
- interstitial lung and liver disease
- organismal death
regulates
- MTORC1
- tRNA-Phe
role in cell
- activation in
- translation in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Farsb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phenylalanyl-tRNA aminoacylation
- protein heterotetramerization
- translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- phenylalanine-tRNA ligase complex
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- RNA binding
- phenylalanine-tRNA ligase activity