Capn5 Gene Summary [Rat]
Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Involved in granulosa cell differentiation; luteinization; and ovarian follicle development. Predicted to be located in cell surface and synapse. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in neovascular inflammatory vitreoretinopathy. Orthologous to human CAPN5 (calpain 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Capn5 |
| Official Name | calpain 5 [Source:RGD Symbol;Acc:620084] |
| Ensembl ID | ENSRNOG00000014251 |
| Bio databases IDs | |
| Aliases | calpain 5 |
| Synonyms | ADNIV, calpain 5, HTRA3, nCL-3, VRNI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Capn5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calpain family cysteine protease
- calpain
- peptidase
- protein binding
- Calpain_III
- CysPc
- C2 domain
Pathways
Biological processes and signaling networks where the Capn5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- vitreoretinopathy neovascular inflammatory
- proliferative vitreoretinopathy
- eosinophilic esophagitis
- hereditary disorder
- runting
- infection by Hepatitis C virus genotype 2
- infection by Hepatitis C virus
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- cell surface
- Nucleus
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Capn5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- synapse
- cell surface
Molecular Function
What the gene product does at the molecular level
- calcium-dependent cysteine-type endopeptidase activity