Kctd7 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including intracellular glutamate homeostasis; intracellular potassium ion homeostasis; and membrane hyperpolarization. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 3. Orthologous to human KCTD7 (potassium channel tetramerization domain containing 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kctd7 |
| Official Name | potassium channel tetramerization domain containing 7 [Source:RGD Symbol;Acc:1582914] |
| Ensembl ID | ENSRNOG00000042384 |
| Bio databases IDs | |
| Aliases | potassium channel tetramerization domain containing 7 |
| Synonyms | 4932409E18, 9430010P06RIK, CLN14, EPM3, FLJ32069, LOC687365, potassium channel tetramerisation domain containing 7, potassium channel tetramerization domain containing 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kctd7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- identical protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- progressive myoclonic epilepsy type 3 with intracellular inclusions
- progressive myoclonic epilepsy type 3 without intracellular inclusions
- progressive myoclonic epilepsy
- hereditary disorder
- neuronal ceroid lipofuscinosis
- progressive myoclonic epilepsy type 3
regulates
- K+
role in cell
- hyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kctd7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular potassium ion homeostasis
- protein homooligomerization
- membrane hyperpolarization
- positive regulation of transporter activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding