Tnfrsf19 Gene Summary [Rat]
Predicted to enable signaling receptor activity. Predicted to be involved in positive regulation of JNK cascade and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within hair follicle development. Predicted to be active in plasma membrane. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf19 |
| Official Name | TNF receptor superfamily member 19 [Source:RGD Symbol;Acc:1564996] |
| Ensembl ID | ENSRNOG00000014265 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 19 |
| Synonyms | RGD1564996, TAJ, TAJ-ALPHA, TAJ-α, TNF receptor superfamily member 19, TRADE, TROY, tumor necrosis factor receptor superfamily, member 19, tumour necrosis factor receptor superfamily, member 19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfrsf19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein binding
- cytosolic tail domain
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- metastasis
- organismal death
- diabetic nephropathy
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
role in cell
- migration
- apoptosis
- growth
- outgrowth
- adipogenesis
- fragmentation
- function
- sorafenib resistance
- sphere formation by
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfrsf19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- hair follicle development
- positive regulation of JNK cascade
- apoptotic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- JNK cascade
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor-activated receptor activity
- signaling receptor activity