Lgr5 Gene Summary [Rat]
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; hair follicle development; and oocyte differentiation. Predicted to be located in trans-Golgi network membrane. Predicted to be active in plasma membrane. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgr5 |
| Official Name | leucine rich repeat containing G protein coupled receptor 5 [Source:RGD Symbol;Acc:1307733] |
| Ensembl ID | ENSRNOG00000004221 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing G protein coupled receptor 5 |
| Synonyms | FEX, GPR49, GPR67, GRP49, HG38, leucine rich repeat containing G protein-coupled receptor 5, LOC687868 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lgr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- protein phosphatase 1 regulatory subunit 42
- ectodomain
- Leucine rich repeat
- 7 transmembrane receptor (rhodopsin family)
- Leucine rich repeat N-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Lgr5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- oral squamous cell carcinoma
- organismal death
- hypopharyngeal squamous cell carcinoma
- melanoma
- melanoma cancer
- oropharyngeal squamous-cell carcinoma
- colorectal cancer
- neoplastic cell transformation
- colon epithelial cancer
role in cell
- apoptosis
- expression in
- proliferation
- phosphorylation in
- binding in
- differentiation
- development
- signaling in
- tumorigenicity
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Golgi Apparatus
- trans Golgi network
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lgr5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- G-protein coupled receptor signaling pathway
- hair follicle development
- positive regulation of canonical Wnt receptor signaling pathway
- oocyte differentiation
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- activation of adenylate cyclase activity
- epithelial cell proliferation involved in renal tubule morphogenesis
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- plasma membrane
- trans-Golgi network membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- transmembrane signaling receptor activity
- protein binding
- protein-hormone receptor activity