Gimap5 Gene Summary [Rat]
Predicted to enable GTP binding activity. Involved in several processes, including negative regulation of metabolic process; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Predicted to be located in lysosomal membrane; mitochondrion; and multivesicular body membrane. Used to study lymphopenia and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to human GIMAP5 (GTPase, IMAP family member 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gimap5 |
| Official Name | GTPase, IMAP family member 5 [Source:RGD Symbol;Acc:628871] |
| Ensembl ID | ENSRNOG00000008416 |
| Bio databases IDs | |
| Aliases | GTPase, IMAP family member 5 |
| Synonyms | GTPase, IMAP family member 5, HIMAP3, IAN4, IAN4L1, IAN-5, IMAP3, IROD, lyp, NCPH2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gimap5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- small GTP-binding protein domain
- membrane-association domain
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AIG1 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- portal hypertension
- noncirrhotic portal hypertension type 2
- coronary artery disease
regulated by
- dexamethasone
- filgrastim
- aldesleukin
- Ebna3c
role in cell
- apoptosis
- permeability
- transmembrane potential
- survival
- dysfunction
- activation
- development
- differentiation
- homeostasis
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gimap5 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- multivesicular body membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding