Tmtc4 Gene Summary [Rat]
Predicted to enable ATPase binding activity and dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein O-linked mannosylation. Predicted to act upstream of or within outer hair cell apoptotic process; positive regulation of endoplasmic reticulum calcium ion concentration; and sensory perception of sound. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human TMTC4 (transmembrane O-mannosyltransferase targeting cadherins 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmtc4 |
| Official Name | transmembrane O-mannosyltransferase targeting cadherins 4 [Source:RGD Symbol;Acc:1560183] |
| Ensembl ID | ENSRNOG00000014310 |
| Bio databases IDs | |
| Aliases | transmembrane O-mannosyltransferase targeting cadherins 4 |
| Synonyms | 4930403J22Rik, 5730419O14Rik, DFNB122, RGD1560183, transmembrane and tetratricopeptide repeat containing 4, transmembrane O-mannosyltransferase targeting cadherins 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmtc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- TPR repeat
- Tetratricopeptide repeats
- type IV pilus biogenesis/stability protein PilW
- Protein O-mannosyl-transferase TMTC, DUF1736
- enzyme
- tetratricopeptide repeat
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- liver neoplasia
- epithelial cancer
- cancer
- liver cancer
- digestive system cancer
- abdominal cancer
- autosomal recessive deafness type 122
- psoriasis
- idiopathic scoliosis
role in cell
- apoptosis
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmtc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- endoplasmic reticulum unfolded protein response
- elevation of endoplasmic reticulum calcium ion concentration
- protein O-linked mannosylation
Cellular Component
Where in the cell the gene product is active
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- mannosyltransferase activity
- ATPase binding
- dolichyl-phosphate-mannose-protein mannosyltransferase activity