Chac1 Gene Summary [Rat]
Predicted to enable Notch binding activity and glutathione specific gamma-glutamylcyclotransferase activity. Predicted to be involved in several processes, including glutathione catabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and negative regulation of Notch signaling pathway. Predicted to be located in cytosol and trans-Golgi network. Predicted to be active in cytoplasm. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chac1 |
| Official Name | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 [Source:RGD Symbol;Acc:1307153] |
| Ensembl ID | ENSRNOG00000014387 |
| Bio databases IDs | |
| Aliases | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
| Synonyms | 1810008K03Rik, ChaC, cation transport regulator 1, ChaC glutathione-specific gamma-glutamylcyclotransferase 1, ChaC glutathione-specific γ-glutamylcyclotransferase 1, MGC4504, RGD1307153 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chac1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amidine lyase
- GGCT_like
- gamma-glutamylcyclotransferase
- enzyme
- protein binding
- notch binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- androgenic alopecia
- dermatomyositis
- cancer cachexia
- age-related macular degeneration
- diabetic nephropathy
regulates
- glutathione
- CHAC1
role in cell
- apoptosis
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chac1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- negative regulation of protein processing
- glutathione biosynthetic process
- glutathione catabolic process
- neurogenesis
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- negative regulation of Notch signaling pathway
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- gamma-glutamylcyclotransferase activity
- Notch binding