C1qbp Gene Summary [Rat]
Enables adrenergic receptor binding activity; complement component C1q complex binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of cell migration; and regulation of intracellular signal transduction. Located in cytoplasm and extracellular space. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1qbp |
| Official Name | complement C1q binding protein [Source:RGD Symbol;Acc:2230] |
| Ensembl ID | ENSRNOG00000006949 |
| Bio databases IDs | |
| Aliases | complement C1q binding protein |
| Synonyms | AA407365, complement C1q binding protein, complement component 1, complement component 1, q subcomponent binding protein, COXPD33, D11Wsu182e, GC1QBP, gC1Q-R, HABP1, P32, p33, SF2AP32, SF2p32 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1qbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mitochondrial presequence
- transcription regulator
- mRNA binding
- transcription co-repressor
- protein binding activity, bridging
- enzyme inhibitor activity
- protein kinase C binding
- G-protein-coupled receptor binding
- transcription factor binding
- protein binding
- Mitochondrial glycoprotein
- binding protein
- ribosome binding
- hyaluronic acid binding
Pathways
Biological processes and signaling networks where the C1qbp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- myocardial fibrosis
- psoriasis
- metastasis
- esophageal carcinoma formation
- combined oxidative phosphorylation deficiency 33
- pancreatic epithelial cancer
- thyroid gland adenocarcinoma
role in cell
- growth
- formation
- formation in
- expression in
- generation in
- phosphorylation in
- apoptosis
- synthesis in
- uptake
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- detergent-insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- plasma membrane projections
- mitochondrial matrix
- acrosome
- synapse
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C1qbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- negative regulation of double-strand break repair via homologous recombination
- positive regulation of cell adhesion
- mature ribosome assembly
- negative regulation of transcription from RNA polymerase II promoter
- protein kinase B signaling cascade
- immune response
- regulation of complement activation
- complement activation, classical pathway
- negative regulation of nuclear mRNA splicing, via spliceosome
- apoptotic process
- positive regulation of dendritic cell chemotaxis
- negative regulation of interferon-gamma production
- negative regulation of RIG-I signaling pathway
- negative regulation of MDA-5 signaling pathway
- positive regulation of neutrophil chemotaxis
- mRNA processing
- positive regulation of substrate adhesion-dependent cell spreading
- response to DNA damage stimulus
- positive regulation of mitochondrial translation
- innate immune response
- positive regulation of apoptotic process
- negative regulation of interleukin-12 production
- negative regulation of defense response to virus
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- cytoplasm
- mitochondrion
- membrane
- cytosol
- extracellular region
- nucleolus
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- mitochondrial ribosome binding
- protein binding
- enzyme inhibitor activity
- transcription corepressor activity
- adrenergic receptor binding
- mRNA binding
- deoxyribonuclease inhibitor activity
- complement component C1q binding
- hyaluronic acid binding
- transcription factor binding
- kininogen binding