Katnb1 Gene Summary [Rat]
Predicted to enable ATPase regulator activity; dynein complex binding activity; and protein heterodimerization activity. Involved in microtubule severing; positive regulation of apoptotic process; and positive regulation of neuron projection development. Located in growth cone; midbody; and neuronal cell body. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Katnb1 |
| Official Name | katanin regulatory subunit B1 [Source:RGD Symbol;Acc:1311256] |
| Ensembl ID | ENSRNOG00000014626 |
| Bio databases IDs | |
| Aliases | katanin regulatory subunit B1 |
| Synonyms | 2410003J24Rik, KAT, katanin p80 (WD40-containing) subunit B 1, katanin regulatory subunit B1, LIS6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Katnb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- conserved domain
- binding protein
- WD40 repeats
- con80 domain of Katanin
- WD domain, G-beta repeat
- WD40
- enzyme
- protein binding
- Ribosome biogenesis protein Nsa1 and similar proteins
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lissencephaly type 6 with microcephaly
- hereditary disorder
- holoprosencephaly
regulates
role in cell
- quantity
- apoptosis
- structure
- development
- severing
- depolymerization
- signaling in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- spindle apparatus
- Plasma Membrane
- centrosome
- microtubules
- midbody
- cytosol
- spindle pole
- growth cone
- cellular protrusions
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Katnb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- protein targeting
- microtubule severing
- positive regulation of apoptotic process
- negative regulation of microtubule depolymerization
- positive regulation of neuron projection development
- cytoplasmic microtubule organization
- mitotic chromosome movement towards spindle pole
- microtubule depolymerization
- positive regulation of microtubule depolymerization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- katanin complex
- spindle pole
- neuronal cell body
- plasma membrane
- microtubule
- growth cone
- nucleus
- centrosome
- cytoplasm
- membrane
- spindle
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- ATPase regulator activity
- protein heterodimerization activity
- dynein complex binding
- microtubule binding