H2az1 Gene Summary [Rat]
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Involved in cellular response to insulin stimulus. Predicted to be located in euchromatin and heterochromatin. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H2AZ1 (H2A.Z variant histone 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | H2az1 |
| Official Name | H2A.Z variant histone 1 [Source:RGD Symbol;Acc:621464] |
| Ensembl ID | ENSRNOG00000010306 |
| Bio databases IDs | |
| Aliases | H2A.Z variant histone 1 |
| Synonyms | H2AFZ, H2AZ, H2A/z, H2A.Z, H2A.Z-1, H2A.Z variant histone 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat H2az1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- binding protein
- double-stranded DNA binding
- C-terminus of histone H2A
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Histone 2A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- metastasis
- psoriasis
- delayed hypersensitive reaction
- hepatocellular carcinoma
- glioma formation
- glioma
role in cell
- expression in
- accumulation in
- activation in
- proliferation
- morphology
- apoptosis
- G1 phase
- binding in
- differentiation
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- autosome
- heterochromatin
- nucleosomes
- chromosomal arms
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat H2az1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to estradiol stimulus
- heterochromatin assembly
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- Barr body
- nucleus
- heterochromatin
- euchromatin
- extracellular vesicular exosome
- nucleosome
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- structural constituent of chromatin
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter sequence-specific DNA binding
- nucleosomal DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding