Ndel1 Gene Summary [Rat]
Enables oligopeptidase activity. Involved in neuron projection development; positive regulation of axon extension; and positive regulation of axon regeneration. Acts upstream of or within nuclear membrane disassembly. Located in several cellular components, including central region of growth cone; centrosome; and nuclear envelope. Part of kinesin complex. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndel1 |
| Official Name | nudE neurodevelopment protein 1-like 1 [Source:RGD Symbol;Acc:621235] |
| Ensembl ID | ENSRNOG00000004139 |
| Bio databases IDs | |
| Aliases | nudE neurodevelopment protein 1-like 1 |
| Synonyms | 2600006O07Rik, Endooligopeptidase, EOPA, MITAP1, mNudE-L, NDE1L1, NDE2, NUDE2, NUDEL, nudE neurodevelopment protein 1-like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndel1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- Dynein light chain binding domain
- cGMP-dependent protein kinase interacting domain
- Tropomyosin like
- peptidase
- NUDE protein, C-terminal conserved region
- coiled-coil domain
- protein binding
- identical protein binding
- phosphorylation site
- microtubule binding
- serine/threonine phosphorylation motif
- endopeptidase
- binding protein
- alpha-tubulin binding
- Growth-arrest specific micro-tubule binding
- Apolipoprotein A1/A4/E domain
- Dynein heavy chain-binding domain
- LIS1 binding domain
Pathways
Biological processes and signaling networks where the Ndel1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- psoriasis
- lissencephaly
role in cell
- apoptosis
- cell death
- formation
- migration
- binding in
- formation in
- degradation in
- quantity
- outgrowth
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- membrane fraction
- intermediate filament cytoskeleton
- transition region of growth cone
- perinuclear region
- centrosome
- granules
- microtubule organizing centers
- cytosol
- centriolar appendages
- spindle pole
- nuclear envelope
- axon hillock
- synaptic vesicles
- growth cone
- neurites
- cell membrane leading edge
- mitotic spindle
- kinetochores
- perikaryon
- axons
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndel1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system neuron axonogenesis
- insulin receptor signaling pathway
- neurofilament cytoskeleton organization
- microtubule nucleation
- chromosome segregation
- cerebral cortex radially oriented cell migration
- mitotic centrosome separation
- positive regulation of ruffle assembly
- positive regulation of GTPase activity
- lysosome localization
- centrosome localization
- establishment of mitotic spindle orientation
- inner cell mass cell proliferation
- vesicle transport along microtubule
- regulation of intracellular protein transport
- regulation of neuron projection development
- cell migration
- establishment of chromosome localization
- retrograde axon cargo transport
Cellular Component
Where in the cell the gene product is active
- centrosome
- cell leading edge
- neurofilament cytoskeleton
- synaptic vesicle
- spindle
- cytosol
- kinesin complex
- kinetochore
- axon hillock
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- beta-tubulin binding
- alpha-tubulin binding
- microtubule binding