Dhdds Gene Summary [Rat]
Predicted to contribute to ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity. Predicted to be involved in dolichol biosynthetic process and dolichyl diphosphate biosynthetic process. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in developmental delay and seizures with or without movement abnormalities and retinitis pigmentosa 59. Orthologous to human DHDDS (dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhdds |
| Official Name | dehydrodolichyl diphosphate synthase subunit [Source:RGD Symbol;Acc:1311560] |
| Ensembl ID | ENSRNOG00000014665 |
| Bio databases IDs | |
| Aliases | dehydrodolichyl diphosphate synthase subunit |
| Synonyms | 3222401G21Rik, cis-IPTase, CIT, CPT, DEDSM, dehydrodolichyl diphosphate synthase, dehydrodolichyl diphosphate synthase subunit, DS, hCIT, HDS, RP59 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dhdds often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cis (Z)-Isoprenyl Diphosphate Synthases
- prenyltransferase
- ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
- dehydrodolichyl diphosphate synthase
- Putative undecaprenyl diphosphate synthase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa type 59
- retinitis pigmentosa
- developmental delay and seizures with or without movement abnormalities
- hereditary disorder
- colon cancer
- retinal dystrophy
- congenital disorders of glycosylation
- congenital disorder of glycosylation type 1bb
regulates
- dolichol monophosphate
- dolichyl diphosphate
- dolichol 20
role in cell
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dhdds gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- polyprenol biosynthetic process
- dolichyl diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- polyprenyltransferase activity
- dehydrodolichyl diphosphate synthase activity