Nus1 Gene Summary [Rat]
Predicted to contribute to ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity. Predicted to be involved in several processes, including lipid biosynthetic process; positive regulation of blood vessel endothelial cell migration; and positive regulation of nitric-oxide synthase activity. Predicted to act upstream of or within cholesterol homeostasis; protein mannosylation; and regulation of intracellular cholesterol transport. Predicted to be located in membrane. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nus1 |
| Official Name | NUS1 dehydrodolichyl diphosphate synthase subunit [Source:RGD Symbol;Acc:1307879] |
| Ensembl ID | ENSRNOG00000000411 |
| Bio databases IDs | |
| Aliases | NUS1 dehydrodolichyl diphosphate synthase subunit |
| Synonyms | 1600027K07Rik, C6orf68, CDG1AA, D10Ertd438e, MGC:7199, MRD55, NgBR, NUS1 dehydrodolichyl diphosphate synthase subunit, RGD1307879, TANGO14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nus1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cis (Z)-Isoprenyl Diphosphate Synthases
- prenyltransferase
- dehydrodolichyl diphosphate synthase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- non-insulin-dependent diabetes mellitus
- autosomal dominant mental retardation 55 with seizures
- congenital disorder of glycosylation type 1aa
- hereditary disorder
- metabolic syndrome X
- congenital disorders of glycosylation
- diabetes mellitus
- congenital bilateral perisylvian polymicrogyria
- type 2 diabetic obesity
role in cell
- phosphorylation in
- loss
- migration
- chemotaxis
- production in
- morphogenesis
- accumulation in
- N-glycosylation in
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nus1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dolichol biosynthetic process
- positive regulation of nitric-oxide synthase activity
- angiogenesis
- regulation of intracellular cholesterol transport
- cell differentiation
- protein glycosylation
- vascular endothelial growth factor signaling pathway
- protein mannosylation
- cholesterol homeostasis
- positive regulation of blood vessel endothelial cell migration
- dolichyl diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- prenyltransferase activity
- dehydrodolichyl diphosphate synthase activity