Elavl4 Gene Summary [Rat]
Enables mRNA 3'-UTR binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of dendrite development; and post-transcriptional regulation of gene expression. Located in several cellular components, including apical dendrite; growth cone; and ribosome. Is active in glutamatergic synapse. Biomarker of hypothyroidism; learning disability; sciatic neuropathy; and status epilepticus. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elavl4 |
| Official Name | ELAV like RNA binding protein 4 [Source:RGD Symbol;Acc:1560027] |
| Ensembl ID | ENSRNOG00000023601 |
| Bio databases IDs | |
| Aliases | ELAV like RNA binding protein 4 |
| Synonyms | Elav, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4, ELAV like RNA binding protein 4, HU-antigen D, HUD, PNEM, RGD1561943, Ribonucleoprotein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Elavl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- mRNA binding
- splicing factor, CC1-like family
- poly(A) binding protein
- protein binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- major depression
- schizophrenia
- cannabis dependence
- diabetic nephropathy
role in cell
- apoptosis
- morphogenesis
- differentiation
- outgrowth
- outgrowth in
- specification
- overgrowth in
- dendritogenesis in
- overgrowth
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polyribosome fractions
- glutaminergic synapse
- ribosome
- Nucleus
- nuclear envelope
- growth cone
- neurites
- perikaryon
- axons
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Elavl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- 3'-UTR-mediated mRNA stabilization
- response to cocaine
- RNA processing
- mRNA processing
- associative learning
- positive regulation of dendrite development
- cerebral cortex neuron differentiation
- dendrite morphogenesis
- locomotory behavior
- regeneration
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- growth cone
- dendrite
- cytoplasm
- perikaryon
- ribosome
- axon
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR AU-rich region binding
- pre-mRNA intronic pyrimidine-rich binding
- poly(A) RNA binding
- mRNA 3'-UTR binding