Galt Gene Summary [Rat]
Enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Involved in UDP-alpha-D-glucose catabolic process and galactose metabolic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in classic galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Galt |
| Official Name | galactose-1-phosphate uridylyltransferase [Source:RGD Symbol;Acc:1306483] |
| Ensembl ID | ENSRNOG00000014766 |
| Bio databases IDs | |
| Aliases | galactose-1-phosphate uridylyltransferase |
| Synonyms | galactose-1-phosphate uridyl transferase, galactose-1-phosphate uridylyltransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Galt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- enzyme
- protein binding
- UDPglucose-hexose-1-phosphate uridylyltransferase
- galactose-1-phosphate uridylyltransferase, family 1
- HIT_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- deficiency of uridine diphosphate-glucose-hexose-1-phosphate uridylyltransferase
- asthma
- galactosemia
- hereditary disorder
- premature ovarian failure
- homozygous Duarte-type classical galactosemia
- endometriosis
regulated by
- oleic acid
- palmitic acid
- HDAC
- HIBCH
- cycloheximide
- SAR1A
regulates
- D-galactose
- glucose-1-phosphate
- galactose
- galactose-1-phosphate
- UDP-D-glucose
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Galt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- galactose catabolic process
- galactose catabolic process via UDP-galactose
- UDP-glucose metabolic process
- galactose metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- UDP-glucose:hexose-1-phosphate uridylyltransferase activity