Vac14 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in phosphatidylinositol biosynthetic process and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of PAS complex. Predicted to be active in endosome membrane and presynaptic endosome. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vac14 |
| Official Name | VAC14 component of PIKFYVE complex [Source:RGD Symbol;Acc:631410] |
| Ensembl ID | ENSRNOG00000017219 |
| Bio databases IDs | |
| Aliases | VAC14 component of PIKFYVE complex |
| Synonyms | ArPIKfyve, D8WSU151E, FLJ10305, ingls, LOC100130369, TAX1BP2, TRX, VAC14 component of PIKFYVE complex, Vac14 homolog (S. cerevisiae) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vac14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- kinase activator
- protein binding
- identical protein binding
- Vacuolar protein 14 C-terminal Fig4p binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- hereditary disorder
- neurodegeneration
- Alzheimer disease
- childhood-onset striatonigral degeneration
- gastroesophageal reflux
- malaria
- peripheral neuropathy
- pancreatic carcinoma
- pancreatic epithelial cancer
role in cell
- production in
- accumulation in
- loss
- invasion by
- aggregation in
- degradation in
- upregulation in
- enlargement in
- vacuolation
- enlargement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- intracellular membranes
- vacuole
- Plasma Membrane
- endosomes
- cytosol
- Golgi membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vac14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- phosphatidylinositol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- PAS complex
- intracellular membrane-bounded organelle
- cytosol
- endosome membrane
- Golgi membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- signaling receptor activity