Arpc3 Gene Summary [Rat]
Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Involved in cellular response to nerve growth factor stimulus. Located in growth cone leading edge. Part of filamentous actin. Used to study Parkinson's disease. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arpc3 |
| Official Name | actin related protein 2/3 complex, subunit 3 [Source:RGD Symbol;Acc:1311985] |
| Ensembl ID | ENSRNOG00000008673 |
| Bio databases IDs | |
| Aliases | actin related protein 2/3 complex, subunit 3 |
| Synonyms | 1110006A04Rik, actin related protein 2/3 complex subunit 3, actin related protein 2/3 complex, subunit 3, ARC21, Arpc3 predicted, p21-Ar, p21-ARC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arpc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- structural constituent of cytoskeleton
- protein binding
- ARP2/3 complex ARPC3 (21 kDa) subunit
Pathways
Biological processes and signaling networks where the Arpc3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Axonal Guidance Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Integrin Signaling
- Phagosome Formation
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse systemic sclerosis
- infection by Dengue virus 2
regulates
- lipid
- actin
- Myelin
- AMPA receptor
- zymosan
- IgG
role in cell
- survival
- formation
- formation in
- maturation
- nucleation
- extension
- phagocytosis by
- migration by
- trafficking
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- actin cytoskeleton
- Nucleus
- actin filaments
- cytosol
- nucleoli
- actin tails
- cell membrane leading edge
- clathrin-coated vesicles
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arpc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- Arp2/3 complex-mediated actin nucleation
- actin polymerization-dependent cell motility
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- site of double-strand break
- focal adhesion
- membrane
- actin cytoskeleton
- cytosol
- filamentous actin
- Arp2/3 protein complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- structural constituent of cytoskeleton