Ptgr1 Gene Summary [Rat]
Enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity and 2-alkenal reductase (NADPH) activity. Involved in several processes, including leukotriene B4 metabolic process; negative regulation of reactive oxygen species biosynthetic process; and response to antineoplastic agent. Located in cytosol and nucleus. Biomarker of hypertension. Orthologous to human PTGR1 (prostaglandin reductase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptgr1 |
| Official Name | prostaglandin reductase 1 [Source:RGD Symbol;Acc:621195] |
| Ensembl ID | ENSRNOG00000015072 |
| Bio databases IDs | |
| Aliases | prostaglandin reductase 1 |
| Synonyms | 2510002C21Rik, DIG-1, LTB4-12-HD, LTB4DH, PGR1, prostaglandin reductase 1, ZADH3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptgr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 15-oxoprostaglandin 13-oxidase
- CH-CH group:NAD or NADP oxidoreductase
- N-terminal domain of oxidoreductase
- MDR
- Zinc-binding dehydrogenase
- CH-OH group:NAD or NADP oxidoreductase
- CH-OH group oxidoreductase
- leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
- putative quinone oxidoreductase, YhdH/YhfP family
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- placenta accreta spectrum
- idiopathic membranous nephropathy
- adenomyosis
regulates
- reactive oxygen species
- leukotriene B4
- 1-pentene-3-one
- prostaglandin
- 15-keto prostaglandin E1
- acrolein
- 4-hydroxy-2(E)-nonenal
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptgr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene B4 metabolic process
- leukotriene metabolic process
- lipoxin A4 metabolic process
- prostaglandin metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- 13-lipoxin reductase activity
- leukotriene B4 12-hydroxy dehydrogenase activity
- 13-prostaglandin reductase activity
- 15-oxoprostaglandin 13-oxidase activity
- 2-alkenal reductase (NADP+) activity