PTGR1 Gene Summary [Human]
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | PTGR1 |
| Official Name | prostaglandin reductase 1 [Source:HGNC Symbol;Acc:HGNC:18429] |
| Ensembl ID | ENSG00000106853 |
| Bio databases IDs | |
| Aliases | prostaglandin reductase 1, zinc binding alcohol dehydrogenase domain containing 3 |
| Synonyms | 2510002C21Rik, DIG-1, LTB4-12-HD, LTB4DH, PGR1, prostaglandin reductase 1, ZADH3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 15-oxoprostaglandin 13-oxidase
- CH-CH group:NAD or NADP oxidoreductase
- N-terminal domain of oxidoreductase
- MDR
- Zinc-binding dehydrogenase
- CH-OH group:NAD or NADP oxidoreductase
- CH-OH group oxidoreductase
- leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
- putative quinone oxidoreductase, YhdH/YhfP family
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- placenta accreta spectrum
- idiopathic membranous nephropathy
- adenomyosis
regulates
- reactive oxygen species
- leukotriene B4
- 1-pentene-3-one
- prostaglandin
- 15-keto prostaglandin E1
- acrolein
- 4-hydroxy-2(E)-nonenal
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene B4 metabolic process
- leukotriene metabolic process
- lipoxin A4 metabolic process
- prostaglandin metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- 13-lipoxin reductase activity
- leukotriene B4 12-hydroxy dehydrogenase activity
- 13-prostaglandin reductase activity
- 15-oxoprostaglandin 13-oxidase activity
- 2-alkenal reductase (NADP+) activity