Necab2 Gene Summary [Rat]
Predicted to enable A2A adenosine receptor binding activity; identical protein binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be involved in positive regulation of protein localization to membrane; regulation of amyloid precursor protein biosynthetic process; and regulation of signal transduction. Is active in postsynapse and presynapse. Orthologous to human NECAB2 (N-terminal EF-hand calcium binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Necab2 |
| Official Name | N-terminal EF-hand calcium binding protein 2 [Source:RGD Symbol;Acc:621844] |
| Ensembl ID | ENSRNOG00000015084 |
| Bio databases IDs | |
| Aliases | N-terminal EF-hand calcium binding protein 2 |
| Synonyms | EFCBP2, NECA2, N-terminal EF-hand calcium binding protein 2, stip-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Necab2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- EF-hand domain pair
- EF hand
- G-protein-coupled receptor binding
- Antibiotic biosynthesis monooxygenase
- EFh
- protein binding
- receptor binding
- identical protein binding
- NIPSNAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- postsynaptic region
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Necab2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of adenosine receptor signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of glutamate receptor signaling pathway
- regulation of amyloid precursor protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- type 5 metabotropic glutamate receptor binding
- protein binding
- calcium ion binding
- A2A adenosine receptor binding