Kpna2

Predicted to enable several functions, including histone deacetylase binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in postsynapse to nucleus signaling pathway and regulation of transcription by glucose. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in several cellular components, including glutamatergic synapse; nuclear membrane; and postsynaptic density. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kpna2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Kpna2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Kpna2 gene, providing context for its role in the cell.