Pou4f1 Gene Summary [Rat]
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | Pou4f1 |
| Official Name | POU class 4 homeobox 1 [Source:RGD Symbol;Acc:620074] |
| Ensembl ID | ENSRNOG00000060662 |
| Bio databases IDs | |
| Aliases | POU class 4 homeobox 1 |
| Synonyms | ATITHS, Brn-3, Brn-3.0, BRN3A, E130119J07RIK, OCT-T1, OCT-T2, POU class 4 homeobox 1, POU domain, class 4, transcription factor 1, RDC-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pou4f1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- non-pou domain
- enzyme binding
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- single-stranded DNA binding
- double-stranded DNA binding
- POU specific domain
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- soft tissue sarcoma cancer
- hypoplasia
- childhood-onset ataxia, intention tremor, and hypotonia syndrome
- aphagia
- rhabdomyosarcoma
- androgenic alopecia
- spondylarthritis
role in cell
- G1 phase
- expression in
- quantity
- transactivation in
- apoptosis
- survival
- outgrowth
- growth
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- neurites
- chromatin
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pou4f1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- trigeminal nerve development
- innervation
- mesoderm development
- central nervous system neuron differentiation
- cell migration in hindbrain
- negative regulation of programmed cell death
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of neuron apoptotic process
- peripheral nervous system neuron development
- regulation of sequence-specific DNA binding transcription factor activity
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- sensory system development
- heart development
- cellular response to estradiol stimulus
- neuron migration
- positive regulation of osteoclast differentiation
- neuron fate specification
- positive regulation of transcription regulatory region DNA binding
- axonogenesis
- suckling behavior
- regulation of cell cycle
- neuron apoptotic process
- neuron projection development
- habenula development
- ventricular compact myocardium morphogenesis
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- synapse assembly
- proprioception involved in equilibrioception
- negative regulation of apoptotic process
- signal transduction by p53 class mediator resulting in induction of apoptosis
- positive regulation of gene expression
- cellular response to cytokine stimulus
- regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- neuron projection
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- single-stranded DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity