Phc1 Gene Summary [Rat]
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in chromatin remodeling and negative regulation of DNA-templated transcription. Predicted to act upstream of or within cellular response to leukemia inhibitory factor and cellular response to retinoic acid. Predicted to be located in nuclear body and sex chromatin. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 11. Orthologous to human PHC1 (polyhomeotic homolog 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phc1 |
| Official Name | polyhomeotic homolog 1 [Source:RGD Symbol;Acc:1309203] |
| Ensembl ID | ENSRNOG00000015191 |
| Bio databases IDs | |
| Aliases | polyhomeotic homolog 1 |
| Synonyms | Edr, EDR1, HPH1, MCPH11, MPH, Mph1, PH1, polyhomeotic 1, polyhomeotic homolog 1, RAE28 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Phc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPM domain
- Sterile alpha motif
- transcription regulator
- Unstructured region on Polyhomeotic-like protein 1 and 2
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- chromatin binding
- protein binding
- protein transduction domain
Pathways
Biological processes and signaling networks where the Phc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nephrosis
- autosomal recessive primary microcephaly 11
- cleft palate syndrome
- stenosis
- collagen-induced arthritis
- hypoplasia
- cleft hard palate
- idiopathic scoliosis
- overriding aorta
- ventricular septal defect
role in cell
- proliferation
- quantity
- activation
- assembly
- development
- signaling in
- killing
- maturation
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perichromatin region
- interchromatin space
- nucleoplasm
- nuclear bodies
- sex chromatin
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Phc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- cellular response to retinoic acid
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PRC1 complex
- PcG protein complex
- sex chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- histone binding
- chromatin binding