Hoxb4 Gene Summary [Rat]
Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in hematopoietic stem cell differentiation; positive regulation of stem cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic skeletal system morphogenesis; hematopoietic or lymphoid organ development; and hemopoiesis. Predicted to be located in centrosome and nucleoplasm. Orthologous to human HOXB4 (homeobox B4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxb4 |
| Official Name | homeo box B4 [Source:RGD Symbol;Acc:1560113] |
| Ensembl ID | ENSRNOG00000008191 |
| Bio databases IDs | |
| Aliases | homeo box B4 |
| Synonyms | B4, homeo box B4, HOX2, HOX-2.6, HOX2F, RGD1560113 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
- YPWMK motif
Pathways
Biological processes and signaling networks where the Hoxb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- herniation
- hypoplasia
- edema
- immune thrombocytopenia
- Crohn disease
- dyspnea
role in cell
- expression in
- proliferation
- cell death
- number
- differentiation
- self-renewal
- hematopoiesis
- quantity
- expansion
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- centrosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior pattern specification
- hemopoietic stem cell differentiation
- spleen development
- morphogenesis of an epithelial sheet
- positive regulation of transcription from RNA polymerase II promoter
- bone marrow development
- embryonic skeletal system morphogenesis
- definitive hemopoiesis
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of stem cell differentiation
- somatic stem cell division
- hemopoietic stem cell proliferation
Cellular Component
Where in the cell the gene product is active
- centrosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity