Trpm3 Gene Summary [Rat]
Predicted to enable calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to act upstream of or within monoatomic cation transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cataract. Orthologous to human TRPM3 (transient receptor potential cation channel subfamily M member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpm3 |
| Official Name | transient receptor potential cation channel, subfamily M, member 3 [Source:RGD Symbol;Acc:1304888] |
| Ensembl ID | ENSRNOG00000027770 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily M, member 3 |
| Synonyms | 6330504P12RIK, AU018608, CTRCT50, GON-2, LTRPC3, MLSN2, NEDFSS, transient receptor potential cation channel subfamily M member 3, transient receptor potential cation channel, subfamily M, member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trpm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetramerization domain of TRPM
- Ion transport protein
- binding protein
- SLOG in TRPM
- calcium channel
- phosphatidylinositol-4,5-bisphosphate binding
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- coronary artery disease
- metabolic syndrome X
- mental retardation
- insulin-dependent diabetes mellitus
- pancreatic epithelial cancer
- restless legs syndrome
- mulibrey nanism
- major depression
- rubella
role in cell
- expression in
- elevation in
- calcium response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trpm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cation transport
- protein tetramerization
- calcium ion transmembrane transport
- metal ion transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium channel activity
- cation channel activity