Obsl1 Gene Summary [Rat]
Involved in Golgi organization and positive regulation of dendrite morphogenesis. Predicted to be located in Golgi apparatus; centrosome; and perinuclear region of cytoplasm. Predicted to be part of 3M complex. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human OBSL1 (obscurin like cytoskeletal adaptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Obsl1 |
| Official Name | obscurin like cytoskeletal adaptor 1 [Source:RGD Symbol;Acc:1306073] |
| Ensembl ID | ENSRNOG00000015346 |
| Bio databases IDs | |
| Aliases | obscurin like cytoskeletal adaptor 1 |
| Synonyms | CLONE 23584, KIAA0657, obscurin-like 1, obscurin like cytoskeletal adaptor 1, RGD1306073 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Obsl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CD19_double_Ig
- FN3
- immunoglobulin domain
- Penicillin-Binding Protein C-terminus Family
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- centrosome
- Golgi Apparatus
- intercellular junctions
- sarcomere
- cytosol
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Obsl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- protein localization in Golgi apparatus
- regulation of mitosis
- Golgi organization
- cardiac myofibril assembly
- microtubule cytoskeleton organization
- positive regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- Z disc
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- intercalated disc
- cytosol
- Golgi apparatus
- M band
Molecular Function
What the gene product does at the molecular level
- cytoskeletal adaptor activity
- protein binding