Xpnpep3 Gene Summary [Rat]
Predicted to enable manganese ion binding activity; metalloaminopeptidase activity; and protein homodimerization activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within glomerular filtration and protein processing. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xpnpep3 |
| Official Name | X-prolyl aminopeptidase 3 [Source:RGD Symbol;Acc:1589063] |
| Ensembl ID | ENSRNOG00000019196 |
| Bio databases IDs | |
| Aliases | X-prolyl aminopeptidase 3 |
| Synonyms | APP3, DJ1057D18.1, E430012M05Rik, ICP55, LOC63929, LOC686766, NPHPL1, X-prolyl aminopeptidase 3, X-prolyl aminopeptidase 3, mitochondrial |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Xpnpep3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metallopeptidase family M24
- Aminopeptidase P, N-terminal domain
- metalloexopeptidase
- methionine aminopeptidase, type I
- peptidase
- aminopeptidase
- protein homodimerization
- protein binding
- APP_MetAP
- manganese ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- nephronophthisis-like nephropathy type 1
- breast carcinoma
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
regulated by
- lipopolysaccharide
- Immunoglobulin
- metformin
- ACHE
regulates
- Mitochondrial ETC 1
role in cell
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Xpnpep3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glomerular filtration
- proteolysis
- protein processing
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- metalloaminopeptidase activity
- manganese ion binding
- aminopeptidase activity