Pak4 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of endothelial cell apoptotic process; positive regulation of angiogenesis; and regulation of MAPK cascade. Predicted to act upstream of or within dendritic spine development. Predicted to be active in cytoplasm. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pak4 |
| Official Name | p21 (RAC1) activated kinase 4 [Source:RGD Symbol;Acc:1307705] |
| Ensembl ID | ENSRNOG00000019883 |
| Bio databases IDs | |
| Aliases | p21 (RAC1) activated kinase 4 |
| Synonyms | 5730488L07Rik, mKIAA1142, p21 (RAC1) activated kinase 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pak4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- p21 binding domain
- Protein kinase (unclassified specificity)
- protein kinase
- regulatory domain
- catalytic domain
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- integrin binding domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- CRIB
- alphaV integrin-binding domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Pak4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- CCR3 Signaling in Eosinophils
- CXCR4 Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- ErbB Signaling
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- Integrin Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Renal Cell Carcinoma Signaling
- Renin-Angiotensin Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
- TNFR1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- metastasis
- diabetic nephropathy
- liver cancer
- hepatic steatosis
- bladder cancer
- hepatocellular carcinoma
- COVID-19
- growth failure
role in cell
- expression in
- apoptosis
- transformation
- phosphorylation in
- proliferation
- growth
- G2/M phase
- binding in
- migration
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- Golgi Apparatus
- intercellular junctions
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pak4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- cytoskeleton organization
- signal transduction
- protein phosphorylation
- dendritic spine development
- positive regulation of angiogenesis
- regulation of cell growth
- apoptotic process
- negative regulation of endothelial cell apoptotic process
- cellular response to organic cyclic compound
- cell migration
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- adherens junction
- focal adhesion
- cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity