Guca1a Gene Summary [Rat]
Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Involved in positive regulation of cGMP-mediated signaling and positive regulation of guanylate cyclase activity. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to several human genes including GUCA1ANB-GUCA1A (GUCA1ANB-GUCA1A readthrough). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Guca1a |
| Official Name | guanylate cyclase activator 1A [Source:RGD Symbol;Acc:1308712] |
| Ensembl ID | ENSRNOG00000015402 |
| Bio databases IDs | |
| Aliases | guanylate cyclase activator 1A |
| Synonyms | AC112683.4, C6orf131, CD-GCAP, COD3, CORD14, GC-A, GCAP, GCAP-1, GCAP-I, guanylate cyclase activator 1A, guanylate cyclase activator 1a (retina), GUCA, GUCA1, LOC102723903, mGCAP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Guca1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- Dockerin type I domain
- calcium sensitive guanylate cyclase activator
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- calcium ion binding
- EFh
- protein binding
- guanylate cyclase regulator
Pathways
Biological processes and signaling networks where the Guca1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cone dystrophy type 3
- nonobstructive azoospermia
role in cell
- activation in
- morphology
- abnormal morphology
- electrophysiology
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- photoreceptor outer segments
- photoreceptor inner segments
- perikaryon
- cone outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Guca1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to calcium ion
- positive regulation of guanylate cyclase activity
- signal transduction
- positive regulation of cGMP-mediated signaling
- visual perception
- phototransduction
Cellular Component
Where in the cell the gene product is active
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- guanylate cyclase regulator activity
- protein binding
- calcium ion binding
- calcium sensitive guanylate cyclase activator activity