Cx3cr1 Gene Summary [Rat]
Enables C-X3-C chemokine receptor activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of cell migration; and regulation of signal transduction. Located in several cellular components, including cell surface; neuronal cell body membrane; and perinuclear region of cytoplasm. Used to study Parkinsonism; glomerulonephritis; hepatopulmonary syndrome; and status epilepticus. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); borna disease; portal hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cx3cr1 |
| Official Name | C-X3-C motif chemokine receptor 1 [Source:RGD Symbol;Acc:620137] |
| Ensembl ID | ENSRNOG00000018509 |
| Bio databases IDs | |
| Aliases | C-X3-C motif chemokine receptor 1 |
| Synonyms | CCRL1, CMKBLR1, CMKBRL1, CMKDR1, C-X3-C motif chemokine receptor 1, Fractalkine receptor, GPR13, GPRV28, mCX3CR1, RBS11, V28 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cx3cr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- C-X3-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- chemokine receptor binding
- C-X3-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- cytokine receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Cx3cr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- migraines
- lupus nephritis
- rheumatoid arthritis
- COVID-19
- septic shock
- fibrosis
- neoplasia
- Parkinson disease
- Alzheimer disease
role in cell
- expression in
- proliferation
- activation
- phosphorylation in
- damage
- survival
- migration
- quantity
- response
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- endosomal membrane
- neurites
- dendritic trees
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cx3cr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of long-term synaptic potentiation
- negative regulation of interleukin-1 beta production
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to wounding
- microglial cell activation involved in immune response
- cell adhesion
- memory
- regulation of nitric oxide biosynthetic process
- positive regulation of angiogenesis
- cell chemotaxis
- chemotaxis
- immune response
- response to ischemia
- regulation of synaptic plasticity
- cellular response to tumor necrosis factor
- calcium-mediated signaling
- social behavior
- G-protein coupled receptor signaling pathway
- central nervous system maturation
- synapse maturation
- positive regulation of monocyte chemotaxis
- regulation of tumor necrosis factor production
- cell-cell signaling
- adaptive immune response
- positive regulation of neuroblast proliferation
- brain development
- phospholipase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- cellular defense response
- cellular response to transforming growth factor beta stimulus
- homeostasis of number of cells in a free-living population
- cellular response to lipopolysaccharide
- innate immune response
- chemokine-mediated signaling pathway
- regulation of synaptic transmission
- positive regulation of neurogenesis
- leukocyte tethering or rolling
- leukocyte chemotaxis
- regulation of neurogenesis
- negative regulation of apoptotic signaling pathway
- positive regulation of protein kinase B signaling cascade
- negative regulation of cell migration
- autocrine signaling
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- external side of plasma membrane
- neuronal cell body membrane
- neuron projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- CX3C chemokine receptor binding
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- C-C chemokine receptor activity
- C-X3-C chemokine binding
- C-X3-C chemokine receptor activity
- chemokine receptor activity