Rd3 Gene Summary [Rat]
Predicted to be involved in several processes, including negative regulation of guanylate cyclase activity; retina development in camera-type eye; and visual perception. Predicted to be located in several cellular components, including perinuclear region of cytoplasm; photoreceptor inner segment; and photoreceptor outer segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 12; and retinal degeneration. Orthologous to human RD3 (RD3 regulator of GUCY2D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rd3 |
| Official Name | retinal degeneration 3, GUCY2D regulator [Source:RGD Symbol;Acc:1593897] |
| Ensembl ID | ENSRNOG00000050766 |
| Bio databases IDs | |
| Aliases | retinal degeneration 3, GUCY2D regulator |
| Synonyms | 3322402L07Rik, C1orf36, LCA12, RD3 regulator of GUCY2D, retinal degeneration 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- RD3 protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- axonemes
- photoreceptor outer segments
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina development in camera-type eye
- negative regulation of guanylate cyclase activity
- protein transport
- visual perception
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- perinuclear region of cytoplasm
- cytoplasm
- photoreceptor inner segment
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- protein binding