Guca1a Gene Summary [Mouse]
This gene encodes a calcium-binding photoreceptor protein. The encoded protein may be involved in modulation of guanylyl cyclase activity, and in turn, the mammalian cone phototransduction cascade. Disruption of this gene results in the retinal degeneration associated with cone dystrophy. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | Guca1a |
| Official Name | guanylate cyclase activator 1a (retina) [Source:MGI Symbol;Acc:MGI:102770] |
| Ensembl ID | ENSMUSG00000023982 |
| Bio databases IDs | |
| Aliases | guanylate cyclase activator 1a (retina) |
| Synonyms | AC112683.4, C6orf131, CD-GCAP, COD3, CORD14, GC-A, GCAP, GCAP-1, GCAP-I, guanylate cyclase activator 1A, guanylate cyclase activator 1a (retina), GUCA, GUCA1, LOC102723903, mGCAP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Guca1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- Dockerin type I domain
- calcium sensitive guanylate cyclase activator
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- calcium ion binding
- EFh
- protein binding
- guanylate cyclase regulator
Pathways
Biological processes and signaling networks where the Guca1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cone dystrophy type 3
- nonobstructive azoospermia
role in cell
- activation in
- morphology
- abnormal morphology
- electrophysiology
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- photoreceptor outer segments
- photoreceptor inner segments
- perikaryon
- cone outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Guca1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to calcium ion
- positive regulation of guanylate cyclase activity
- signal transduction
- positive regulation of cGMP-mediated signaling
- visual perception
- phototransduction
Cellular Component
Where in the cell the gene product is active
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- guanylate cyclase regulator activity
- protein binding
- calcium ion binding
- calcium sensitive guanylate cyclase activator activity