Vil1 Gene Summary [Rat]
Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phospholipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including actin cytoskeleton organization; regulation of actin filament organization; and regulation of cell morphogenesis. Predicted to be located in several cellular components, including brush border; filopodium tip; and ruffle. Orthologous to human VIL1 (villin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vil1 |
| Official Name | villin 1 [Source:RGD Symbol;Acc:1307048] |
| Ensembl ID | ENSRNOG00000015408 |
| Bio databases IDs | |
| Aliases | villin 1 |
| Synonyms | D2S1471, VIL, Villin, villin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vil1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol 4,5-biphosphate binding domain
- phospholipid binding
- caspase inhibitor activity
- alpha helix
- calcium ion binding
- protein binding
- identical protein binding
- actin filament binding
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- binding protein
- Gelsolin repeat
- phosphatidylinositol-4,5-bisphosphate binding
- protein homodimerization
- Villin headpiece domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- Turner syndrome
- pancreatic neoplasm
- pancreatic neoplasia
- Klinefelter syndrome
- neonatal sepsis
regulates
- actin
- F Actin
- G-actin (family)
- protein-protein complex
role in cell
- reorganization
- morphogenesis
- migration
- depolymerization
- nucleation
- severing
- migration by
- assembly
- motility
- actin capping
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- ruffle
- actin cytoskeleton
- Plasma Membrane
- brush border
- microvilli
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vil1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- epidermal growth factor receptor signaling pathway
- cytoplasmic actin-based contraction involved in cell motility
- positive regulation of multicellular organism growth
- regulation of actin nucleation
- apoptotic process
- positive regulation of epithelial cell migration
- macromolecular complex assembly
- regulation of wound healing
- actin polymerization or depolymerization
- positive regulation of lamellipodium morphogenesis
- actin filament depolymerization
- regulation of lamellipodium morphogenesis
- actin filament polymerization
- epithelial cell differentiation
- barbed-end actin filament capping
- intestinal D-glucose absorption
- response to bacterium
- actin filament severing
- actin filament capping
- positive regulation of actin filament depolymerization
- cellular response to hepatocyte growth factor stimulus
- cellular response to epidermal growth factor stimulus
- regulation of microvillus length
- positive regulation of actin filament bundle assembly
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- brush border
- cytoplasm
- microvillus
- actin cytoskeleton
- actin filament bundle
- ruffle
- filopodium tip
- filopodium
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- identical protein binding
- protein binding
- protein homodimerization activity
- lysophosphatidic acid binding
- calcium ion binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process