Avil Gene Summary [Rat]
Enables actin binding activity. Involved in nervous system development and positive regulation of neuron projection development. Located in neuron projection. Human ortholog(s) of this gene implicated in nephrotic syndrome type 21. Orthologous to human AVIL (advillin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Avil |
| Official Name | advillin [Source:RGD Symbol;Acc:620301] |
| Ensembl ID | ENSRNOG00000050419 |
| Bio databases IDs | |
| Aliases | advillin |
| Synonyms | ADVIL, advillin, DOC6, NPHS21, p92, Putative actin binding protein doc6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Avil often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- binding protein
- Gelsolin repeat
- actin binding
- Villin headpiece domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- focal adhesions
- actin cytoskeleton
- actin filaments
- neurites
- cellular protrusions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Avil gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lamellipodium assembly
- barbed-end actin filament capping
- actin filament severing
- regulation of diacylglycerol biosynthetic process
- cilium morphogenesis
- actin polymerization or depolymerization
- nervous system development
- actin filament organization
- positive regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- actin cytoskeleton
- actin filament
- cell projection
- neuron projection
- axon
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- actin binding
- Arp2/3 complex binding